107334-06-5
107334-06-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28333 英文別名
PD 1383127-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
應(yīng)用領(lǐng)域
用途一
PD 138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally.