107254-86-4
中文名稱(chēng)
5-硝基-2-(3-苯丙胺)苯甲酸
英文名稱(chēng)
NPPB
CAS
107254-86-4
分子式
C16H16N2O4
分子量
300.31
MOL 文件
107254-86-4.mol
更新日期
2025/01/07 18:51:26
107254-86-4 結(jié)構(gòu)式
基本信息
中文別名
5-硝基-2-(3-苯丙胺)苯甲酸 英文別名
NPPBC13705
Compound 144
Recombinant Human NPPB Protein, His Tag
5-NITRO-2-(3-PHENYLPROPYLAMINO)-BENZOATE
5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC ACID
5-NITRO-2-(3'-PHENYLPROPYL-AMINO)BENZOIC ACID
3-Nitro-6-[(3-phenylpropyl)amino]benzoic acid
5-Nitro-2-(3-phenylpropylamino)benzoic acid,NPPB
5-NITRO-2-(3-PHENYLPROPYLAMINO)-BENZOIC ACID 98%
物理化學(xué)性質(zhì)
熔點(diǎn)178-180℃
沸點(diǎn)523.5±50.0 °C(Predicted)
密度1.323±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度ethanol: 3 mg/mL
溶解度乙醇：3 mg/mL
酸度系數(shù)(pKa)2.27±0.22(Predicted)
形態(tài)黃色固體
顏色Light yellow to yellow
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
生物活性
NPPB 是外向整流氯化物通道 (ORCC) 的阻斷劑。靶點(diǎn)
ORCC
體外研究
0.1 mM NPPB in the bath solution reduces channel open probability from 0.89±0.06 to 0.11±0.04 (n=5, P<0.01). Dose-dependent inhibition of chloride currents is observed with a 50% inhibitory concentration (IC 50 ) of 125 μM NPPB. NPPB itself also shows cytotoxicity against glioma cells with a GI 50 of approximately 500 μM.