1064662-40-3
1064662-40-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12944 英文別名
SNT-207707FBNJDWPWZNPVSC-UHFFFAOYSA-N
IMidazo[1,2-a]pyridine-6-carboxaMide, 2-(4-cyanophenyl)-N,N-bis(3-Methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-, hydrochloride (1:1)
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMSO: ≥ 250 mg/mL (454.40 mM); Methanol: 250 mg/mL (454.40 mM)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
SNT-207707是一種有效，選擇性，有口服活性的黑素皮質(zhì)素受體 (melanocortin MC-4) 拮抗劑，IC50 值為8 nM (結(jié)合) 和5 nM (功能)。靶點(diǎn)
IC50: 8 nM (binding MC-4), 5 nM (function MC-4)
體外研究
SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5.
體內(nèi)研究
Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss.