106362-32-7
中文名稱
106362-32-7
英文名稱
ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE
CAS
106362-32-7
分子式
C35H55N9O16
分子量
857.86
MOL 文件
106362-32-7.mol
更新日期
2025/01/10 21:28:03
106362-32-7 結(jié)構(gòu)式
基本信息
中文別名
肽TPEPTIDE T
ASTTTNYT
多肽T H-ALA-SER-THR-THR-THR-ASN-TYR-THR-OH
英文別名
ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATEAla-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt
L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-
L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-
物理化學性質(zhì)
沸點1499.5±65.0 °C(Predicted)
密度1.432±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度Soluble in DMSO
酸度系數(shù)(pKa)3.21±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Peptide T是源自HIV-1 gp120的V2區(qū)的八肽。 Peptide T是 CD4 受體的配體，可阻止 HIV 與CD4受體結(jié)合。靶點
CD4, HIV
體外研究
Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC.
體內(nèi)研究
Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE.