105737-62-0
中文名稱
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
CAS
105737-62-0
分子式
C23H25F3N4O5.CH4O3S
分子量
590.57
MOL 文件
105737-62-0.mol
105737-62-0 結(jié)構(gòu)式
基本信息
英文別名
CGP207122HClCGP 20712 mesylate
CGP 20712 DIHYDROCHLORIDE
CGP-20712A methanesulfonate salt
CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE
CGP-20712A methanesulfonate salt solid, >=98% (HPLC)
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
常見問題列表
生物活性
CGP 20712 A (CGP 20712 mesylate) 是一種高選擇性 β1-adrenoceptor 拮抗劑，IC50 為 0.7 nM，是對 β2 腎上腺素受體的選擇性約為 10,000 倍。靶點
IC50: 0.7 nM (β1-adrenoceptor)
體外研究
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
體內(nèi)研究
Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.