105226-30-0
中文名稱
化合物 T27340
英文名稱
1H-[1,4]Benzodioxino[2,3-c]pyrrole, 5-fluoro-2,3,3a,9a-tetrahydro-, hydrochloride (1:1), (3aR,9aR)-
CAS
105226-30-0
分子式
C10H11ClFNO2
分子量
231.65
MOL 文件
105226-30-0.mol
105226-30-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27340 英文別名
GR50360GR-50360
GR 50360
Fluparoxan HCl
Fluparoxan hydrochloride
1H-[1,4]Benzodioxino[2,3-c]pyrrole, 5-fluoro-2,3,3a,9a-tetrahydro-, hydrochloride (1:1), (3aR,9aR)-
應(yīng)用領(lǐng)域
用途一
Fluparoxan, also known as GR-50360; GR-50360A, is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). It was shown to possess central α2-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.