1049741-03-8
中文名稱
TNF-α inhibitor
英文名稱
TNF-α inhibitor
CAS
1049741-03-8
分子式
C32H33ClF3N3O2
分子量
584.08
MOL 文件
1049741-03-8.mol
1049741-03-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲存條件4°C, away from moisture
溶解度DMSO : 11.36 mg/mL (18.31 mM; ultrasonic and warming and heat to 60°C)
形態(tài)白色粉末狀固體。
顏色White to off-white
常見問題列表
生物活性
SPD304 dihydrochloride 是腫瘤壞死因子 α (TNF-α) 的選擇性抑制劑，能夠促進(jìn)腫瘤壞死因子三聚體的分離，從而阻斷其與受體間的相互作用。SPD304 體外抑制腫瘤壞死因子 α 和受體 1 間結(jié)合的 IC50 值為 22 μM。靶點(diǎn)
IC50: 22 μM (TNFα).
體外研究
SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation.
體內(nèi)研究
SPD304 cannot be used in vivo due to its high toxicity.