10448-84-7
10448-84-7 結(jié)構(gòu)式
基本信息
中文別名
硝米芬 英文別名
CI628Nitromifen
Nitromifene
1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine
Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
常見問題列表
生物活性
Nitromifene 是一個(gè)雌激素受體 (ER) 拮抗劑。靶點(diǎn)
ER
體外研究
Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase.