103898-38-0
103898-38-0 結構式
基本信息
中文別名
化合物 T16897 英文別名
SM 65863-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-[3-[[methyl(phenylmethyl)amino]methyl]-1,2,4-oxadiazol-5-yl]-4-(3-nitrophenyl)-, methyl ester
物理化學性質(zhì)
熔點127-128 °C
沸點624.0±65.0 °C(Predicted)
密度1.270±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.10±0.50(Predicted)
常見問題列表
生物活性
SM-6586 是一種 calcium channel 的拮抗劑，同時能夠抑制 Na+/H+ 和 Na+/Ca2+ exchange transport，主要用于研究腦血管疾病和高血壓等疾病。體內(nèi)研究
In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group.