102676-47-1
基本信息
AROMATASE抑制劑(FADROZOLE)
4-(5,6,7,8-四氫咪唑[1,5-A]吡啶-5-基)苯腈
4-(5,6,7,8-四氫咪唑并[1,5-A]吡啶-5-基)苯腈
4-(5,6,7,8-四氫咪唑并[1,5-Α]吡啶-5-基)苯腈
4-(5,6,7,8-四氫咪唑并[1,5-A]吡啶-5-基)苯甲腈
FAD286
CS-2710
FAD 286)
CGS-16949
FADROZOLE
CGS-169494
FADROZOLE USP/EP/BP
Fadrozole (CGS 16949A
Fadrozole Hydrochloride Hydrate
物理化學性質(zhì)
鹽酸法屈唑(Fadrozole Hydrochloride):C14H13N3?HCl。[102676-96-0]。從異丙醇結(jié)晶,熔點231--233℃。溶于水。
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-14247A | 法倔唑 Fadrozole | 102676-47-1 | 5mg | 660元 |
2024/11/08 | HY-14247A | 法倔唑 Fadrozole | 102676-47-1 | 10mM * 1mLin DMSO | 726元 |
2024/11/08 | HY-14247A | 法倔唑 Fadrozole | 102676-47-1 | 10mg | 880元 |
常見問題列表
Target | Value |
Aromatase
() | 4.5 nM |
Fadrozole hydrochloride is a very potent inhibitor of both human placental and rat ovarian aromatase. In hamster ovarian slices, fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of fadrozole hydrochloride. .
Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values.