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1021950-79-7

中文名稱(chēng) 金蓮花堿
英文名稱(chēng) 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
CAS 1021950-79-7
分子式 C12H13NO3
分子量 219.24
MOL 文件 1021950-79-7.mol
1021950-79-7 結(jié)構(gòu)式 1021950-79-7 結(jié)構(gòu)式

基本信息

中文別名
馬齒莧酰胺E
英文別名
Trolline
Oleracein E
Trolline((±)-Trolline)
Trolline((±)-Trolline)
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-

應(yīng)用領(lǐng)域

用途一
Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation.
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