1018675-35-8
中文名稱
CS-2863
英文名稱
CVT-12012
CAS
1018675-35-8
分子式
C21H21F3N4O3
分子量
434.41
MOL 文件
1018675-35-8.mol
更新日期
2024/10/12 11:25:53
1018675-35-8 結(jié)構(gòu)式
基本信息
中文別名
化合物CVT-12012 英文別名
CS-2863CVT-2012
CVT-12012
2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide
Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-
2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide
物理化學(xué)性質(zhì)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 1 mg/ml
酸度系數(shù)(pKa)13.29±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
常見問題列表
生物活性
CVT-12012 是一種有效的、具有口服活性的硬脂酰-CoA 去飽和酶 (SCD) 的抑制劑，其對(duì)大鼠微粒體和人 HEPG2 的 IC50 值分別為 38 nM，6.1 nM。靶點(diǎn)
IC50: 38 nM (rat microsomal), 6.1 nM (human HEPG2).
體外研究
CVT-12012 (Compound 5b) displays the highest potency in both the microsomal and the HEPG2 SCD assays (IC 50 38 nM and 6.1 nM, respectively) compared to the other methyl-substituted compounds.
體內(nèi)研究
In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h.