10129-56-3
中文名稱
Α-(三氯甲基)-4-吡啶乙醇
英文名稱
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
CAS
10129-56-3
分子式
C8H8Cl3NO
分子量
240.51
MOL 文件
10129-56-3.mol
10129-56-3 結(jié)構(gòu)式
基本信息
中文別名
Α-(三氯甲基)-4-吡啶乙醇ALPHA-(三氯甲基)-4-吡啶乙醇
英文別名
PETCMAPOPTOSIS ACTIVATOR I
α-(Trichloromethyl)-4-pyridineethanol
a-(Trichloromethyl)-4-pyridineethanol
4-Pyridineethanol, α-(trichloromethyl)-
1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
物理化學(xué)性質(zhì)
沸點(diǎn)342.2±37.0 °C(Predicted)
密度1.465±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度DMSO: 22 mg/mL, soluble
溶解度DMSO：22 mg/mL，可溶
酸度系數(shù)(pKa)12.07±0.20(Predicted)
形態(tài)solid
顏色Light yellow to light brown
常見問題列表
生物活性
PETCM 是 caspase-3 的激活劑，以細(xì)胞色素 c (cyto c) 依賴的方式起作用。PETCM 可促進(jìn) Apaf-1 低聚化，可誘導(dǎo) HeLa 細(xì)胞的凋亡 (apoptosis)。靶點(diǎn)
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Caspase 3
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體外研究
PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP.PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM.PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells.
Western Blot Analysis
| Cell Line: | HeLa cells |
| Concentration: | 0.2 mM |
| Incubation Time: | 1 hour |
| Result: | Increased apoptosome formation. |