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ChemicalBook--->CAS DataBase List--->98457-88-6

98457-88-6

98457-88-6 Structure

98457-88-6 Structure
IdentificationBack Directory
[Name]

aminopterin N-hydroxysuccinimide ester
[CAS]

98457-88-6
[Synonyms]

Nhs-aminopterin
N-Hydroxysuccinimide aminopterin
aminopterin N-hydroxysuccinimide ester
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid
[Molecular Formula]

C24H25N9O7
[MOL File]

98457-88-6.mol
Hazard InformationBack Directory
[Description]

Aminopterin N-hydroxysuccinimide ester is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.
98457-88-6 suppliers list
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