| Identification | Back Directory | [Name]
HUMAN IL-1BETA | [CAS]
97599-21-8 | [Synonyms]
HUMAN EP
HIL-1BETA
HUMAN MCF
HUMAN LAF
HUMAN LEM
RHIL-1BETA
HUMAN IL-1B
IL-1B, HUMAN
IL-1F2 (HUMAN)
HUMAN IL-1BETA
HUMAN CATABOLIN
IL-1 BETA, HUMAN
HUMAN INTERLEUKIN-1BETA
RECOMBINANT HUMAN IL-1B
HUMAN ENDOGENOUS PYROGEN
INTERLEUKIN-1BETA, HUMAN
HUMAN MONONUCLEAR CELL FACTOR
HUMAN LYMPHOCYTE-ACTIVATING FACTOR
HUMAN LEUKOCYTE ENDOGENOUS MEDIATOR
INTERLEUKIN-1BETA, HUMAN, RECOMBINANT
98% (HPLC), suitable for cell culture
Interleukin-1β, Human, Recombinant, E. coli
INTERLEUKIN,HUMAN,RECOMBINANT,CELLCULTUREGRADE
Interleukin-1beta (IL-1beta),human,recombinant
IL-1BETA IL-1 LYMPHOCYTE ACTIVATING FACTOR HUMAN | [MDL Number]
MFCD00131399 |
| Hazard Information | Back Directory | [Uses]
IL-1β (interleukin 1 β) human has been used to study the effect of pro- and anti-inflammatory mediators on leukotriene B4 and C4 synthesis as well as secretion in an inflamed porcine endometrium. It has been used to study the effect of cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs. | [General Description]
IL-1β (interleukin 1 β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. It is synthesized as a pro-IL-1β which is changed to active form IL-1β with the help of pro-inflammatory protease caspase-1. IL-1β belongs to the IL-1 gene family. The gene is mapped to human chromosome 2q14. Recombinant human IL-1β is a 17.3kDa protein containing 153 amino acid residues. | [Biochem/physiol Actions]
Both IL-1α (interleukin 1 α) and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF (fibroblast growth factor)-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. IL-1β is involved in proinflammatory and immunological responses. Some of them include enhancing IL-2 generation, and increasing circulating NO (nitric oxide) and bringing neutrophils. It also regulates gene expression of inflammatory cytokines, mesenchymal growth factors and colony stimulating factors. IL-1β is present in chronic inflamed tissues and also in tissues going for fibrogenesis. It brings neutrophil and macrophage to the site of infection. Mutations in IL-1β gene are linked with renal manifestations and renal sequelae in Henoch-Sch?nlein purpura. It is also associated with destruction of β-cell in type 1 diabetes. |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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