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ChemicalBook--->CAS DataBase List--->95734-82-0

95734-82-0

95734-82-0 Structure

95734-82-0 Structure
IdentificationBack Directory
[Name]

Nedaplatin
[CAS]

95734-82-0
[Synonyms]

254-s
Aqupla
Nedaplait
NEDAPLATIN
NSC 375101D
Nedaplatin, >=99%
Nedaplatin USP/EP/BP
Nedaplatin (NSC 375101D)
cis-diammine(glycolato)platinum(ii)
(glycolato-o,o')diammineplatinum(ii)
cis-diamine-glycolate-O,O'-platinum(II)
cis-Diammine(glycolato(2-)O,O')platinum
Cis-diammine-glycoloato-O,O'-platinum(II)
platinum(2+) azanide- hydroxyacetic acid(1:2:1)
2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one
(SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum
PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-, (SP-4-3)-
o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
o(sup 2))- diammine(hydroxyacetato(2-)-o(sup 1 (sp-4-3)-platinu (glycolato-o,o')diammineplatinum(ii) 254-s cis-diammine(glycolato)platinum(ii) nedaplatin nsc 375101d
[Molecular Formula]

C2H8N2O3Pt
[MDL Number]

MFCD00866374
[MOL File]

95734-82-0.mol
[Molecular Weight]

303.17
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
[form ]

Powder
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Description]

Nedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.
[Originator]

Shionogi (Japan)
[Uses]

anticancer
[Brand name]

Aqupla
[Pharmaceutical Applications]

Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin. The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular, ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect is myelosuppression.
Spectrum DetailBack Directory
[Spectrum Detail]

Nedaplatin(95734-82-0)1HNMR
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