| Identification | Back Directory | [Name]
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE | [CAS]
94-19-9 | [Synonyms]
setd
etazol
etazole
aethazol
sethadil
globucid
ethazole
globucin
globuzid
berlophen
sul-spantab
sulfaethidol
sul-spansion
sulfaethidole
sulphaethidole
sulfaethidiole
sulfa-perlongit
TIMTEC-BB SBB001155
sulfaethylthiadiazole
ethazole(pharmaceutical)
2-sulfanilamidoaethylthiodiazol
n-(5-ethyl-1,3,4-thiadiazol-2-yl)-sulfanilamid
n-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfanilamide
Sulphanyl acid N-(5-ethyl-1,3,4-thiadiazol-2yl) amide
4-amino-n-(5-ethyl-1,3,4-thiadiazol-2-yl)-benzenesulfonamid
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide
Benzenesulfonamide, 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)- | [EINECS(EC#)]
202-312-4 | [Molecular Formula]
C10H12N4O2S2 | [MDL Number]
MFCD00057224 | [MOL File]
94-19-9.mol | [Molecular Weight]
284.36 |
| Chemical Properties | Back Directory | [Melting point ]
185.5-186.0° | [density ]
1.3410 (rough estimate) | [refractive index ]
1.6440 (estimate) | [pka]
pKa 5.36(H2O
t = 37) (Uncertain) | [Water Solubility ]
215mg/L(20 ºC) |
| Hazard Information | Back Directory | [Originator]
Sul-Spansion,SKF,US,1956 | [Definition]
ChEBI: 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is a member of benzenes and a sulfonamide. | [Manufacturing Process]
0.163 mol of 2-amino-5-ethyl-1,3,4-thiadiazole was covered with 43 parts of
anhydrous pyridine. To the mixture was added 50 parts (0.214 mol) of pacetylaminobenzenesulfonyl
chloride with vigorous shaking at 50°C to 60°C.
The reaction mixture was then heated to 125°C. When the mixture had cooled
somewhat it was placed in a Claisen flask and 27.6 parts (0.69 mol) of
sodium hydroxide dissolved in 110 parts of water was added through a
dropping funnel while distilling off a mixture of pyridine and water. The
distillation was stopped when the temperature reached 100°C and the residual
liquor in the flask heated at 95°C for 30 minutes.The reaction mixture was then poured into 1,650 parts of hot water, the pH
adjusted to 8 to 9, decolorizing charcoal was added and the whole was heated
on the steam for 15 minutes. The charcoal was filtered off and the hot filtrate
neutralized and cooled. The 2-(sulfanilamido)-5-ethyl-1,3,4-thiadiazole was
purified by repeated crystallization from boiling water. | [Therapeutic Function]
Antibacterial |
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