| Identification | Back Directory | [Name]
Propargyl-PEG3-amine | [CAS]
932741-18-9 | [Synonyms]
Alkyne-PEG3-NH2
HC≡C-CH2-PEG3-NH2
Propyne-PEG3-amine
PROPARGYL-PEG3-NH2
Azido-PEG3-propargyl
Propargyl-PEG3-amine
Propargyl-PEG3-azide
3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)prop-1-yne | [Molecular Formula]
C9H15N3O3 | [MDL Number]
MFCD20720810 | [MOL File]
932741-18-9.mol | [Molecular Weight]
213.24 |
| Hazard Information | Back Directory | [Biological Activity]
Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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