| Identification | Back Directory | [Name]
PPQ-102 | [CAS]
931706-15-9 | [Synonyms]
CS-1365
PPQ-102
CFTR Inhibitor
PPQ 102, >=98%
PPQ-102, CFTR Inhibitor
CFTR INHIBITOR; PPQ102; PPQ 102
CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin
6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-
6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102
PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione | [Molecular Formula]
C26H22N4O3 | [MDL Number]
MFCD14824240 | [MOL File]
931706-15-9.mol | [Molecular Weight]
438.48 |
| Chemical Properties | Back Directory | [Melting point ]
>300℃ (ethanol ) | [Boiling point ]
648.7±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
DMF: 0.2 mg/ml | [form ]
White crystalline solid | [pka]
1.00±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [General Description]
A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture. | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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