| Identification | Back Directory | [Name]
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [CAS]
927670-97-1 | [Synonyms]
Thalidomide-NH-CH2-COOH
6-dioxopiperidin-3-yl)-1
3-dioxoisoindolin-4-yl)glycine
3-dioxoisoindol-4-yl]amino]acetic acid
(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid | [Molecular Formula]
C15H13N3O6 | [MDL Number]
MFCD31667076 | [MOL File]
927670-97-1.mol | [Molecular Weight]
331.28 |
| Chemical Properties | Back Directory | [Boiling point ]
713.9±60.0 °C(Predicted) | [density ]
1.637±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 50 mg/mL (150.93 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.92±0.10(Predicted) | [InChI]
InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22) | [InChIKey]
LRGLFYOYKPSPJQ-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Hazard Information | Back Directory | [Definition]
Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).
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