| Identification | Back Directory | [Name]
Rp-8-bromo-Cyclic AMPS (sodium salt) | [CAS]
925456-59-3 | [Synonyms]
Rp-isomer
Rp-8-bromo-cAMPS
8-Bromoadenosine 3'
Rp-8-bromo-Cyclic AMPS
5'-cyclic monophosphorothioate
Rp-8-bromo-Cyclic AMPS (sodium salt)
RP-8-BR-CAMPS;8-BROMOADENOSINE 3';5'-CYCLIC MONOPHOSPHOROTHIOATE; RP-ISOMER;RP-8-BROMO-CAMPS;925456-59-3 | [Molecular Formula]
C10H12BrN5NaO5PS | [MOL File]
925456-59-3.mol | [Molecular Weight]
448.16 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.1,2 It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.2 | [storage]
Store at -20°C | [References]
1. Dostmann, W.R., Taylor, S.S., Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates J. Biol. Chem. 265(18),10484-10491(1990).
2. Gjertsen, B.T., Mellgran, G., Otten, A., et al. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β action J. Biol. Chem. 270(35),20599-20607(1995). |
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