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ChemicalBook--->CAS DataBase List--->925434-55-5

925434-55-5

925434-55-5 Structure

925434-55-5 Structure
IdentificationBack Directory
[Name]

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
[CAS]

925434-55-5
[Synonyms]

SRT1720 free base/ STR1720 HCl salt
SRT1720 - CAS 925434-55-5 - Calbiochem
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide
2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-
N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide
Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
[Molecular Formula]

C25H23N7OS
[MDL Number]

MFCD14584468
[MOL File]

925434-55-5.mol
[Molecular Weight]

469.56
Chemical PropertiesBack Directory
[Melting point ]

221℃
[density ]

1.46
[storage temp. ]

-20C
[solubility ]

DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM)
[form ]

Yellow solid
[pka]

11.19±0.70(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[General Description]

A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).
[storage]

Store at -20°C
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