| Identification | Back Directory | [Name]
2-AG-D8 | [CAS]
924894-97-3 | [Synonyms]
2-AG-D8
NOLADIN-D8
2-ARACHIDONOYL GLYCEROL-D8
RCRCTBLIHCHWDZ-FBFLGLDDSA-N
5Z,8Z,11Z,14Z-EICOSATETRAENOIC-5,6,8,9,11,12,14,15-D8 ACID, 2-GLYCERYL ESTER | [Molecular Formula]
C23H30D8O4 | [MDL Number]
MFCD02259351 | [MOL File]
924894-97-3.mol | [Molecular Weight]
386.59 |
| Hazard Information | Back Directory | [Description]
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism. | [Definition]
ChEBI: 2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol. It has a role as a human metabolite. It is an endocannabinoid and a 2-acylglycerol 20:4. It is functionally related to an arachidonic acid. |
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