| Identification | Back Directory | [Name]
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one | [CAS]
92285-87-5 | [Synonyms]
L82-G17
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one | [Molecular Formula]
C11H9ClN4O2 | [MOL File]
92285-87-5.mol | [Molecular Weight]
264.67 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);472.29(Max Conc. mM) | [form ]
Solid | [pka]
9.16±0.10(Predicted) | [color ]
Pink to orange |
| Hazard Information | Back Directory | [Description]
L82-G17 is a selective uncompetitive inhibitor of DNA ligase I (LigI). | [Uses]
3-Hydroxy-benzaldehyde (5-Chloro-6-oxo-1,6-dihydro-pyridazin-4-yl)-hydrazone can be used to determine the structure-activity relationships among DNA ligase inhibitors. | [in vitro]
Among the LigI-selective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells._x000D_
_x000D_
Reference: DNA Repair (Amst). 2017 Dec;60:29-39. https://pubmed.ncbi.nlm.nih.gov/29078112/ | [target]
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. |
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DC Chemicals
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021-58447131 13564518121 |
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