| Identification | Back Directory | [Name]
RO 25-6981 HYDROCHLORIDE | [CAS]
919289-58-0 | [Synonyms]
Ro 256981 HCl
Ro 25-6981 HCl
Ro 25 6981 HCl
Ro 25-6981 hydrochloride hydrate
4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride
[R-(R*,S*)]-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL HYDROCHLORIDE
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate | [Molecular Formula]
C22H30ClNO2 | [MDL Number]
MFCD02684414 | [MOL File]
919289-58-0.mol | [Molecular Weight]
375.93 |
| Hazard Information | Back Directory | [Uses]
Ro 25-6981 hydrochloride hydrate has been used:
- as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
- as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
- to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus
| [Biochem/physiol Actions]
Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. |
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