| Identification | Back Directory | [Name]
NOSCAPINE HYDROCHLORIDE | [CAS]
912-60-7 | [Synonyms]
NOSCAPINEHCL
opianhydrochloride
capvalhydrochloride
lyobexhydrochloride
nsc5366hydrochloride
vadebexhydrochloride
NOSCAPINE BASE / HCL
NOSCAPINE EP STANDARD
opianinehydrochloride
terbenolhydrochloride
nectadonhydrochloride
longatinhydrochloride
coscopinhydrochloride
coscotabshydrochloride
narcosinehydrochloride
NOSCAPINE USP STANDARD
tusscapinehydrochloride
narcomprenhydrochloride
NOSCAPINE HYDROCHLORIDE
NARCOTINE HYDROCHLORIDE
Noscapine HCl(Nectodon)
l-Narcotine hydrochloride
key-tusscapinehydrochloride
1-alpha-narcotinehydrochloride
methoxyhydrastinehydrochloride
Narcotine HCl((S,R)-Noscapine)
NOSCAPINE HYDROCHLORIDE USP/EP/BP
Noscapine hydrate hydrochloride
Narcotine, hydrochloride (7CI, 8CI)
NoscapineHydrochlorideMonohydrate>
Noscapine hydrochloride hydrate,Narcotine hydrochloride
,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-
1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1
6,7-Dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one hydrochloride
(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonehydrochloride
(3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDROCHLORIDE
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, hydrochloride, [S-(R*,S*)]-
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (9CI) | [EINECS(EC#)]
213-014-9 | [Molecular Formula]
C22H24ClNO7 | [MDL Number]
MFCD00082546 | [MOL File]
912-60-7.mol | [Molecular Weight]
449.88 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder or colourless crystals, hygroscopic. | [Melting point ]
221-223 °C(lit.) | [storage temp. ]
2-8°C
| [solubility ]
Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand. | [form ]
neat | [color ]
Crystals | [Merck ]
13,6752 | [EPA Substance Registry System]
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder or colourless crystals, hygroscopic. | [Uses]
Anti-Tussive | [Uses]
topical fluoroquinolone antibiotic for acne | [Biological Activity]
Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent. | [Safety Profile]
Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
22 | [Safety Statements ]
36 | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
NP7225000
| [F ]
10 | [HS Code ]
2939.19.5000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Toxicity]
cyt-ham:fbr 60 mg/L ESKHA5 96,55,78 |
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