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ChemicalBook--->CAS DataBase List--->91-84-9

91-84-9

91-84-9 Structure

91-84-9 Structure
IdentificationBack Directory
[Name]

PYRILAMINE
[CAS]

91-84-9
[Synonyms]

Pyra
rd2786
Parmal
Dipane
Histan
Isamin
rp2786
Stamine
Stangen
Kriptin
Enrumay
Coradon
Nisaval
Nyscaps
RP 2786
Pyramal
Mepyren
Histasan
Anhistol
Antamine
Anthisan
Histacap
Histalon
Statomin
Thylogen
NSC13136
NSC-13136
NSC 13136
Maranhist
Copsamine
Afko-Hist
Anhistabs
Triaminic
Harvamine
Mepyramin
R.d. 2786
Paraminyl
Neo-Bridal
Pyrilamide
Mepyramine
NCI-C60651
Antalergan
Dorantamin
Mepiramine
Histapyran
PYRILAMINE
Antallergan
Neoantergan
Pyranisamine
MEPYRAMINE BASE
Pyrilamine base
PYRILAMINE USP/EP/BP
Pyrilamine(mepyramine)
MEPYRAMINE(PYRILAMINE)
MEPYRAMINE (PYRILAMINE) BASE
Wait's Green mountain antihistamine
Pyrilamine (base and/or unspecified salts)
p-methoxybenzyl-alpha-pyridyl-dimethyl-aethylendiamin
p-Methoxy-benzyl-alpha-pyridyl-dimethyl-aethylendiamin
2-dimethylaminoethyl-(4-methoxybenzyl)-(2-pyridyl)amine
2-((2-dimethylaminoethyl)(p-methoxybenzyl)amino)pyridine
2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine
2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine
2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin
2-((2-(dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine
N-p-methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine
Pyridine, 2-((p-methoxybenzyl)(2-(dimethylamino)ethyl)amino)-
Pyridine, 2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]-
n-(p-methoxybenzyl)-n’,n’-dimethyl-n-2-pyridylethylenediamine
N',N'-Dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine
N-(p-Methoxybenzyl)-N',N'-dimethyl-N-2-(pyridylethylene)diamine
n-p-methoxybenzyl-n’,n’-dimethyl-n-alpha-pyridylethylenediamine
N-(p-Methoxybenzyl)-N',N'-dimethyl-N-2-pyridyl-1,2-ethanediamine
n-(para-methoxybenzyl)-n’,n’-dimethyl-n-2-pyridylethylenediamine
N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2 -Pyridyl)ethylenediamine
n-para-methoxybenzyl-n’,n’-dimethyl-n-alpha-pyridylethylenediamine
Ethylenediamine, N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)-
N-(4-Methoxy-benzyl)-N,N-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine
N-(p-Methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine
N-Dimethylamino-aethyl-N-p-methoxy-benzyl-alpha-amino-pyridin-maleat
N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(alpha-pyridyl)-ethylenediaminene
N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine
n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-1,2-ethanediamine
1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridyl-
N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine
1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-
1,2-Ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-
[EINECS(EC#)]

202-102-2
[Molecular Formula]

C17H23N3O
[MDL Number]

MFCD00023451
[MOL File]

91-84-9.mol
[Molecular Weight]

285.38
Chemical PropertiesBack Directory
[Melting point ]

131-132 °C
[Boiling point ]

bp5 201°; bp0.06 168-172°
[density ]

1.0141 (rough estimate)
[refractive index ]

nD25 1.5760-1.5765
[pka]

pKa 4.02(H2O t=25 c=0.002 to 0.01) (Uncertain);8.92 (Uncertain)
[Water Solubility ]

3.425g/L(37.5 ºC)
[EPA Substance Registry System]

Mepyramine (91-84-9)
Safety DataBack Directory
[Hazardous Substances Data]

91-84-9(Hazardous Substances Data)
[Toxicity]

LD50 orally in mice: 312 mg/kg (Schlichtergroll)
Hazard InformationBack Directory
[Uses]

Antihistaminic.
[Uses]

N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine also known as pyrilamine works in synergism with diclofenac as a therapeutic alternative for clinical management of inflammatory pain.
[Uses]

Pyrilamine is also used for allergy symptoms and rhinitis.
[Definition]

ChEBI: An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
[Brand name]

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).
[Synthesis Reference(s)]

Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037
[General Description]

Viscous brown liquid.
[Air & Water Reactions]

May be sensitive to light. Insoluble in water.
[Reactivity Profile]

PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
[Health Hazard]

SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.
[Fire Hazard]

Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.
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