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ChemicalBook--->CAS DataBase List--->909-39-7

909-39-7

909-39-7 Structure

909-39-7 Structure
IdentificationBack Directory
[Name]

OPIPRAMOL DIHYDROCHLORIDE
[CAS]

909-39-7
[Synonyms]

ensidon
insidondihydrochloride
opipramolhydrochloride
Opipramol dihydrochloride >=98% (HPLC), solid
4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride
4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride
4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadiclori
5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc
Opipramol DihydrochlorideQ: What is Opipramol Dihydrochloride Q: What is the CAS Number of Opipramol Dihydrochloride Q: What is the storage condition of Opipramol Dihydrochloride
[EINECS(EC#)]

213-000-2
[Molecular Formula]

C23H31Cl2N3O
[MDL Number]

MFCD00941483
[MOL File]

909-39-7.mol
[Molecular Weight]

436.418
Chemical PropertiesBack Directory
[Melting point ]

210° (FR M209); mp 228-230° (DE 1133729)
[solubility ]

H2O: ~24 mg/mL
[form ]

solid
[color ]

yellow
Safety DataBack Directory
[Hazard Codes ]

Xn,N
[Risk Statements ]

22-50/53
[Safety Statements ]

60-61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

3
[RTECS ]

TL9100000
Hazard InformationBack Directory
[Originator]

Insidon,Geigy,W. Germany,1962
[Uses]

antidepressant, antipsychotic;'sigma antagonist
[Manufacturing Process]

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
[Therapeutic Function]

Antidepressant, Antipsychotic
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