| Identification | Back Directory | [Name]
MI 63 | [CAS]
908027-21-4 | [Synonyms]
MI 63
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | [Molecular Formula]
C29H35Cl2FN4O3 | [MOL File]
908027-21-4.mol | [Molecular Weight]
577.52 |
| Hazard Information | Back Directory | [Description]
MI-63 is a potent, specific, non-peptide inhibitor of the MDM2-p53 interaction. | [Definition]
ChEBI: MI-63 is an azaspiro compound resulting from the formal fusion of position 3 of 6-chloro-oxindole with position 3 of (2R,3SS5S)-3-(3-chloro-2-fluorophenyl)-5-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]pyrrolidine-2-carboxamide. It is a potent inhibitor of the MDM2-p53 interaction. It has a role as an apoptosis inducer. It is an azaspiro compound, a member of morpholines, a member of oxindoles, a member of pyrrolidines, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. |
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