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ChemicalBook--->CAS DataBase List--->906805-06-9

906805-06-9

906805-06-9 Structure

906805-06-9 Structure
IdentificationBack Directory
[Name]

Necitumumab
[CAS]

906805-06-9
[Synonyms]

Necitumumab
IMC-11F8/LY301221
Necitumumab (anti-EGFR)
Research Grade Necitumumab(DHB86901)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Clinical Use]

IgG1 monoclonal antibody:
Treatment of locally advanced or metastatic epidermal growth factor receptor (EGFR) expressing squamous non-small cell lung cancer
[Drug interactions]

Potentially hazardous interactions with other drugs
Live vaccines: avoid concomitant use.
[Metabolism]

The elimination routes of necitumumab are only partially documented, and involve degradation to peptides after being internalised into its target cells, proteolysis within the liver or the reticuloendothelial system, as well as nonspecific endocytosis.
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