| Identification | Back Directory | [Name]
1-Naphthalenecarboxylic acid, 2-[[[2-[(1Z)-3-(dimethylamino)-1-propen-1-yl]-4-fluorophenyl]sulfonyl]amino]-5,6,7,8-tetrahydro- | [CAS]
904680-01-9 | [Synonyms]
1-Naphthalenecarboxylic acid, 2-[[[2-[(1Z)-3-(dimethylamino)-1-propen-1-yl]-4-fluorophenyl]sulfonyl]amino]-5,6,7,8-tetrahydro- | [Molecular Formula]
C22H25FN2O4S | [MOL File]
904680-01-9.mol | [Molecular Weight]
432.51 |
| Hazard Information | Back Directory | [Description]
A-849519 is a reversible inhibitor of MetAP2 that has demonstrated anti-angiogenesis and anticancer activity in a number of in vitro and in vivo models. In this study, we evaluated the anticancer activity of A-849519 in a modified Dunning model of androgen-independent prostate cancer and compared its efficacy with TNP-470, an established MetAP2 inhibitor. |
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