| Identification | Back Directory | [Name]
POLYETHYLENEIMINE, BRANCHED | [CAS]
9002-98-6 | [Synonyms]
PEI-7
PEI-10
PEI-15
PEI-30
PEI-35
PEI-45
PEI-250
PEI-275
PEI-700
PEI-14M
PEI-1000
PEI-1400
PEI-1500
PEI-1750
PEI-2500
25987-06-8
EPOMIN P-1000
EPOMIN P-1050
EPOMIN SP-003
EPOMIN SP-200
Polyethyleneimine
(ca. 30% in Water)
Ethylene iMine polyM
Aziridine,homopolymer
PolyethyleneiMine
Polyethylenimine, linear
polyethylenimine(10,000)
polyethylenimine(20,000)
polyethylenimine(35,000)
polyethylenimine(40,000)
Ethyleneimine,homopolymer
Ethyleneimine resin (50%)
MODIFIEDPOLYETHYLENEIMINE
POLYETHYLENEIMINE, 50% SOLN
POLYETHYLENEIMINE, BRANCHED
Poly(ethyleneimine) solution
Ethyleneimine polymer solution
Ethylene imine polymer solution
Polyethyleneimine (30% in Water)
POLY(ETHYLENEIMINE) SOLUTION 10%
Polyethyleneimine,Mw70,000Solution
Polyethyleneimine,Mw50,000Solution
Polyethyleneimine (ca. 30% in Water)
polyethyleneimine, branched, m.w. 600
Polyethyleneimine, linear, M.W. 25,000
Ethyleneimine polymer solution, PEI
polyethyleneimine, branched, m.w. 1800
Polyethyleneimine,branched,M.W.1800,99%
polyethyleneimine, branched, m.w. 10,000
polyethyleneimine, branched, m.w. 70,000
Poly(ethyleneiMine) solution ~50% in H2O
POLYETHYLENEIMINE,50%(V/V)AQUEOUSSOLUTION
polyethylenimine 50% (W/V) aqueous*solution
ETHYLENE IMINE POLYMER SOLUTION, 50% IN WATER
PolyethyleniMine, linear average Mn 2,500, PDI <1.2
Polyethylenimine, linear average Mn 5,000, PDI <1.2
Polyethyleneimine,branched,M.W.70,000,30%w/vaq.soln.
POLYETHYLENIMINE AV. MOL. WT. APPROX.*50 ,000 50% (W
Polyethylenimine, linear average Mn 10,000, PDI <=1.2
PolyethyleniMine, Branched, Av. Mn (by GPC) Approx. 10,000
Polyethyleneimine (ca. 30% in Water) [for Biochemical Research]
Poly(ethyleneimine) solution,Ethyleneimine polymer solution, PEI
Polyethylenimine hydrochloride linear, average Mn 4,000, PDI <=1.1
Polyethylenimine hydrochloride linear, average Mn 20,000, PDI <=1.2
PolyethyleneiMine on silica beads, anion exchange resin, 20-40 Mesh
PolyethyleneiMine on silica beads, anion exchange resin, 40-200 Mesh
Polyethyleneimine, approx. M.N. 60,000, 50 wt% aq. solution, branched
Polyethyleneimine, branched, M.W. 50,000-100,000, 30% w/w aq. soln.
Polyethyleneimine, approx. M.W. 60,000, 50 wt% aq. solution, branched
PolyethyleneiMine, approx. M.W. 60,000, 50 wt% aq. solution, branched 100GR
PolyethyleneiMine on silica beads, anion exchange resin, benzylated, 20-40 Mesh
PolyethyleneiMine on silica beads, anion exchange resin, benzylated, 40-200 Mesh
Poly(ethyleneiMine) solution average Mn ~1,200, average Mw ~1300 by LS, 50 wt. % in H2O
PolyethyleniMine, branched average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched
Poly(ethyleneiMine) solution average Mn ~1,800 by GPC, average Mw ~2,000 by LS, 50 wt. % in H2O
Poly(ethyleneiMine) solution average Mn ~60,000 by GPC, average Mw ~750,000 by LS, 50 wt. % in H2O | [EINECS(EC#)]
205-793-9 | [Molecular Formula]
H(NHCH2CH2)nNH2 | [MDL Number]
MFCD00803910 | [MOL File]
9002-98-6.mol | [Molecular Weight]
43.07 |
| Questions And Answer | Back Directory | [Description]
Polyethyleneimine (PEI), an organic polyamine polymer, is one of the
most prominent examples of cationic polymers capable of gene
transfection in vitro and in vivo into various cell lines and
tissues. PEI was also applied in different fields from gene therapy
and several studies have emphasized the importance of this polymer in
medicinal chemistry. |
| Chemical Properties | Back Directory | [Appearance]
Clear viscous liquid | [Melting point ]
59-60°C | [Boiling point ]
250 °C(lit.)
| [density ]
1.030 g/mL at 25 °C
| [vapor pressure ]
9 mmHg ( 20 °C) | [refractive index ]
n20/D 1.5290
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
DMSO (Sparingly) | [form ]
Liquid | [color ]
Pale yellow | [Specific Gravity]
1.045 (20/4℃) | [PH]
pH(50g/l, 25℃) : 10～12 | [Water Solubility ]
Soluble in water. | [Sensitive ]
Hygroscopic | [InChI]
InChI=1S/C2H5N/c1-2-3-1/h3H,1-2H2 | [InChIKey]
NOWKCMXCCJGMRR-UHFFFAOYSA-N | [SMILES]
C1NC1 | [LogP]
-0.969 (est) | [EPA Substance Registry System]
Aziridine, homopolymer (9002-98-6) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear viscous liquid | [Usage]
Used as a polyelectrolyte multilayer on charged surfaces to provide a biocompatible coating on surfaces.1Detergents, adhesives, water treatment, printing inks, dyes, cosmetics, and paper industry, adhesion promoter, lamination primer, fixative agent, flocculant, cationic dispersant, stability enhancer, surface activator, chelating agent, scavenger for aldehydes and oxides. | [Uses]
Polyethyleneimine is used as a polyelectrolyte multilayer on charged surfaces to provide a biocompatible coating on surfaces.1Detergents, adhesives, water treatment, printing inks, dyes, cosmetics, and paper industry, adhesion promoter, lamination primer, fixative agent, flocculant, cationic dispersant, stability enhancer, surface activator, chelating agent, scavenger for aldehydes and oxides.
| [Application]
Polyethyleneimine(PEI) can be used as a non-viral synthetic polymer carrier for in vivo delivery of therapeutic nucleic acids. The interaction between the negatively charged nucleic acid and the positively charged polymer backbone leads to the formation of nanoscale complexes. This neutralising complex protects the enclosed nucleic acid from enzymes and maintains its stability until cellular uptake occurs. For example, human serum albumin-coupled PEI shows good pDNA transfection and low toxicity.
PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs can be used for CO2 uptake and gene delivery.
Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified aqueous zirconia/PAN nanofibres have a high fluoride adsorption capacity and a wide working pH range, and can therefore be used for groundwater defluoridation.
| [Definition]
ChEBI: Aziridine is a saturated organic heteromonocyclic parent, a member of aziridines and an azacycloalkane. It has a role as an alkylating agent. It is a conjugate base of an aziridinium. | [Production Methods]
Polyethylenimine is produced by the homopolymerization of ethylenimine. The reaction is catalyzed by acids, Lewisacids, or haloalkanes. The polymerization is usually carried out at 90 – 110 ℃ in water or in a variety of organic solvents. The average molecular mass of the polyethylenimine prepared as described above is 10 000 – 20 000. Higher molecular mass polymers are prepared by addition of a difunctional alkylating agent, such as chloromethyloxirane or 1,2-dichloroethane. Polyethylenimines with a higher average molecular mass can also be provided by ultrafiltration of polymers with a broad mass distribution. Likewise, polymers of lower molecular mass can be obtained by inclusion of a low molecular mass amine, such as 1,2- ethanediamine, during polymerization. By using these techniques a range of molecular masses from 300 to 10 6 can be obtained. Cross-linking during the polymerization of ethylenimine in organic solvents leads to solid polyethylenimines. Furthermore the polymerization process can be conducted on the surface of organic or inorganic materials, thus fixing the polyethylenimines to a support.
| [General Description]
All polyethylene imine polymers are hydrophilic and may contain approx. 30% hydrated water. | [Trade name]
Lupasol, Polymin, Catiofast, Lugalvan (BASF), Epomin (Nippon Shokubai).
| [Biological Activity]
Polyethylenimine is nondegradable and the molecular weight of PEI affects the cytotoxicity and gene transfer activity. Polyethylenimine acts as a low toxicity and efficient gene vector.
| [Structure and conformation]
Polyethyleneimine(PEI) exists as both a branched and linear structure. Branched PEI (bPEI) is synthesized via acid-catalyzed polymerization of aziridine, whereas the linear structure (lPEI) is synthesized via ring opening polymerization of 2-ethyl-2-oxazoline followed by hydrolysis.
|
|
|