| Identification | Back Directory | [Name]
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester | [CAS]
890190-22-4 | [Synonyms]
WDR5-0103
WDR50103, >98%
WD-Repeat Protein 5-0103
WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103
Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester | [Molecular Formula]
C21H25N3O4 | [MDL Number]
MFCD07086826 | [MOL File]
890190-22-4.mol | [Molecular Weight]
383.44 |
| Chemical Properties | Back Directory | [Boiling point ]
495.2±45.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
12.96±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones. WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 μM). | [Uses]
3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic Acid Methyl Ester is an small molecule inhibitor of WDR5, an essential componet of the human trithorax-like famliy of SET1 methyltransferase complexes that carry out trimethylation of histone 3 Lys4. | [storage]
Store at +4°C |
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