| Identification | Back Directory | [Name]
8-OXO-2'-DEOXYGUANOSINE | [CAS]
88847-89-6 | [Synonyms]
8-Oxodeoxyguanosine
2-Amino-9-((2R,4S,5R)
-3H-purine-6,8(7H,9H)
2'-Deoxy-8-oxoguanosine
8-hydroxydeoxyguanosine
8-OXO-2'-DEOXYGUANOSINE
2'-Deoxy-8-oxo-D-guanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-oxo-7-hydrodeoxyguanosine
2'-Deoxy-8-hydroxyguanosine
8-Oxo-7,8-dihydrodeoxyguanosine
7,8-Dihydro-8-oxo-2'-deoxyguanosine
7,8-dihydro-2’-deoxy-8-oxo-guanosin
7,8-dihydro-2’-deoxy-8-oxoguanosine
8-Oxo-7,8-dihydro-2'-deoxyguanosine
Guanosine,2'-deoxy-7,8-dihydro-8-oxo-
8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG
8-Hydroxy-2'-deoxyguanosineDiscontinued See O850250
8-Hydroxy-2′-deoxyguanosine,8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
2-azanyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,7-dihydropurine-6,8-quinone
2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione | [Molecular Formula]
C10H13N5O5 | [MDL Number]
MFCD03788705 | [MOL File]
88847-89-6.mol | [Molecular Weight]
283.24 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
217-220°C | [density ]
2.25±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in DMSO (up to 10 mg/ml). | [form ]
White to off-white solid. | [pka]
7.86±0.20(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro | [Definition]
ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage. | [Description]
8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3 | [Biochem/physiol Actions]
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis | [References]
1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636
2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221
3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41 |
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