| Identification | Back Directory | [Name]
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- | [CAS]
886212-98-2 | [Synonyms]
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- | [Molecular Formula]
C20H40BrNO3 | [MOL File]
886212-98-2.mol | [Molecular Weight]
422.44 |
| Hazard Information | Back Directory | [Biological Activity]
SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM).1 It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 μM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 μM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 μM. | [storage]
-20°C | [References]
1.Camacho, L., Meca-Cortés, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013)
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