| Identification | Back Directory | [Name]
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride | [CAS]
883976-12-3 | [Synonyms]
M8-B
M8-B hydrochloride
M8-B hydrochloride >=98% (HPLC)
N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride | [Molecular Formula]
C22H25ClN2O3S | [MDL Number]
MFCD27978374 | [MOL File]
883976-12-3.mol | [Molecular Weight]
432.964 |
| Hazard Information | Back Directory | [Description]
M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. | [Uses]
M8 B Hydrochloride is a channel blocker of cold receptor TRPM8. | [storage]
Store at +4°C |
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