天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->881487-77-0

881487-77-0

881487-77-0 Structure

881487-77-0 Structure
IdentificationBack Directory
[Name]

2-[[4-[[[4-(tert-Butyl)phenyl]sulfonyl]imino]-1-oxo-1,4-dihydro-2-naphthyl]thio]acetic Acid
[CAS]

881487-77-0
[Synonyms]

KPT-6566
KPT 6566;KPT6566;881487-77-0
2-[[4-[[[4-(tert-Butyl)phenyl]sulfonyl]imino]-1-oxo-1,4-dihydro-2-naphthyl]thio]acetic Acid
Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]imino]-1,4-dihydro-1-oxo-2-naphthalenyl]thio]-
[Molecular Formula]

C22H21NO5S2
[MDL Number]

MFCD05803546
[MOL File]

881487-77-0.mol
[Molecular Weight]

443.54
Chemical PropertiesBack Directory
[Boiling point ]

622.4±65.0 °C(Predicted)
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light, stored under nitrogen
[solubility ]

DMSO: soluble
[form ]

A solid
[pka]

3.52±0.10(Predicted)
[color ]

White to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Biological Activity]

Potent and selective peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 covalent inhibitor with anti-cancer efficacy in cultures and in vivo.

KPT-6566 is a potent and selective peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 inhibitor (IC50 = 640 nM) th at targets Pin1 catalytic site for covalent modificationresulting in Pin1 degradation and the release of ROS-generating and DNA-damaging quinone-mimicking KPT-6566-B. KPT-6566 inhibits the proliferation of wild-typebut not Pin1-/-MEFs (1-5 μM for 48h) with concomitant reduction of cellular pRB and Cyclin D1 hyperphosphorylation. KPT-6566 induces cancer cell death in cultures (1-10 μM for 48h) and reduces MDA-MB-231 lung metastasis in mice in vivo (5 mg/kg/d i.p.). KPT-6566 is more potent than juglone and does not affect the PPIase activity of GST-FKBP4 or GST-PPIA.
881487-77-0 suppliers list
Company Name: Accela ChemBio Inc.
Tel: +1-858-6993322
Website: www.accelachem.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Website: http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
Website: http://www.jm-bio.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Shanghai Maclean Biochemical Technology Co., LTD  
Tel: 021-50706066 15221275939
Website: http://www.macklin.cn/
Company Name: Accela ChemBio Co.,Ltd.  
Tel: 021-50795510 4000665055
Website: https://www.shao-yuan.com
Company Name:   
Tel:
Website: www.sangon.com
Company Name: Hainan Huaxiang Pharmaceutical Technology Co., Ltd.  
Tel: 18389863383
Website: www.approvedhomemanagement.com/showsupplierproductslist360663/0.htm
Company Name: Neobioscience Co., Ltd.  
Tel: 4006-800-892
Website: www.nbs-bio.com
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121
Website: www.absin.cn
Company Name: Proteintech China  
Tel: 027-87531629
Website: www.ptgcn.com
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Website: www.caymanchem.com
Company Name: MedChemExpress  
Tel: 021-58955995
Website: www.medchemexpress.com
Tags:881487-77-0 Related Product Information