| Identification | Back Directory | [Name]
(-)-Denudatin B | [CAS]
87402-88-8 | [Synonyms]
C10554
(-)-Denudatin B
(-)-Denudatin B
(2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydrobenzofuran-6-one | [Molecular Formula]
C21H24O5 | [MOL File]
87402-88-8.mol | [Molecular Weight]
356.41 |
| Chemical Properties | Back Directory | [Boiling point ]
491.1±45.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Oil | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: Denudatin B is a member of benzofurans. | [Biological Activity]
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action | [References]
[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47. [2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130. |
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