| Identification | Back Directory | [Name]
LEPTOMYCIN A | [CAS]
87081-36-5 | [Synonyms]
PD-118607
NSC 369326
Antibiotic ATS-1287A
Antibiotic PD-118607
LEPTOMYCIN A USP/EP/BP
QECBVZBMGUAZDL-DLWOFZAMSA-N
ATS 1287A, PD 118607, JildaMycin
19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)- | [Molecular Formula]
C32H46O6 | [MDL Number]
MFCD01711669 | [MOL File]
87081-36-5.mol | [Molecular Weight]
526.7 |
| Chemical Properties | Back Directory | [Fp ]
9℃ | [storage temp. ]
-20°C | [solubility ]
Ethanol: Soluble; Methanol: Soluble | [form ]
methanol solution | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.1 Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Item No. 10004976) with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours.2 Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent. | [Uses]
Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. | [Definition]
ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17. | [IC 50]
HIV-1 |
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