| Identification | Back Directory | [Name]
Bischloroanthrabenzoxocinone | [CAS]
866022-28-8 | [Synonyms]
BABX
Bischloroanthrabenzoxocinone
6,16-Epoxy-14H-anthra[2,3-d][1]benzoxocin-14-one, 10,12-dichloro-6,7,9,16-tetrahydro-11,13,15-trihydroxy-3-methoxy-1,6,9,9-tetramethyl-, (6R,16R)- | [Molecular Formula]
C28H24Cl2O7 | [MDL Number]
MFCD14635432 | [MOL File]
866022-28-8.mol | [Molecular Weight]
543.392 |
| Chemical Properties | Back Directory | [Melting point ]
167-169 °C(Solv: nitromethane (75-52-5)) | [Boiling point ]
660.1±55.0 °C(Predicted) | [density ]
1.475±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A residue | [pka]
4.60±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). The receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells. | [storage]
Store at -20°C |
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Lynnchem
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Energy Chemical
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