| Identification | Back Directory | [Name]
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole | [CAS]
862808-01-3 | [Synonyms]
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole | [Molecular Formula]
C22H22BrN5OS | [MDL Number]
MFCD05897677 | [MOL File]
862808-01-3.mol | [Molecular Weight]
484.41 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Predicted) | [solubility ]
DMF: 1 mg/ml; DMSO: Slightly soluble | [form ]
A crystalline solid | [pka]
6.56±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50 = 313 nM).1 It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = >100 μM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing Cas9 (H460Cas9). It sensitizes A549, Huh7, HCC1143, U2OS, SU-DHL-5, and T98G cancer cells to ferroptosis induced by (1S,3R)-RSL3 when used at concentrations ranging from 10 to 1,000 nM. FSEN1 also sensitizes H460Cas9 cells, but not FSP1-/- H460 cells, to cell death induced by the ferroptosis inhibitors dihydroartemisinin or FINO2 . | [References]
1. Hendricks, J.M., Doubravsky, C., Wehri, E., et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis bioRxiv ,(2022). |
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