| Identification | Back Directory | [Name]
15-DEOXY-DELTA12,14-PROSTAGLANDIN D2 | [CAS]
85235-11-6 | [Synonyms]
QUGBPWLPAUHDTI-PLGLXCLHSA-N
15-deoxy-Δ12,14-Prostaglandin D2
15-DEOXY-DELTA12,14-PROSTAGLANDIN D2
9ALPHA,HYDROXY-11-OXO-PROSTA-5Z,12E,14E-TRIEN-1-OIC ACID | [Molecular Formula]
C20H30O4 | [MDL Number]
MFCD00797638 | [MOL File]
85235-11-6.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [solubility ]
DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >5 mg/ml (from PGD2) |
| Hazard Information | Back Directory | [Description]
15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 . It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM. 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 μg/ml). It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2. |
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