| Identification | Back Directory | [Name]
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE | [CAS]
83654-05-1 | [Synonyms]
U-57908
Rg 80267
RHC-80267
RXSVYGIGWRDVQC-UHFFFAOYSA-N
RHC-80267 - CAS 83654-05-1 - Calbiochem
1,6-bis(cyclohexyloximinocarbonyl)hexane
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908
O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime
N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine)
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE ISO 9001：2015 REACH
Cyclohexanone, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]
(cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
Cyclohexanone O-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl) oxime | [Molecular Formula]
C20H34N4O4 | [MDL Number]
MFCD00210844 | [MOL File]
83654-05-1.mol | [Molecular Weight]
394.52 |
| Chemical Properties | Back Directory | [Melting point ]
118-121℃ | [density ]
1.21±0.1 g/cm3(Predicted) | [RTECS ]
GW1485000 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: 9 mg/mL
| [form ]
solid
| [pka]
13.81±0.46(Predicted) | [color ]
white
| [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| Hazard Information | Back Directory | [Description]
RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1 | [Uses]
RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid. | [Definition]
ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound. | [General Description]
Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α. | [Biological Activity]
Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M). | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
Store at +4°C | [References]
1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006
2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247
3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509
4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673
5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717 |
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