| Identification | Back Directory | [Name]
3-BROMO-4-CHLOROANILINE | [CAS]
823-54-1 | [Synonyms]
3-BROMO-4-CHLOROANILINE
3-Bromo-4-chlorobenzenamine
3-Bromo-4-chlorophenylamine
3-Bromo-4-chloroaniline >
BenzenaMine,3-broMo-4-chloro- | [Molecular Formula]
C6H5BrClN | [MDL Number]
MFCD00173905 | [MOL File]
823-54-1.mol | [Molecular Weight]
206.468 |
| Chemical Properties | Back Directory | [Melting point ]
82°C | [Boiling point ]
290.6±20.0℃ (760 Torr) | [density ]
1.722±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
129.5±21.8℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder to crystal | [pka]
2.89±0.10(Predicted) | [color ]
White to Brown |
| Hazard Information | Back Directory | [Description]
3-Bromo-4-chloroaniline can be used as an intermediate in pharmaceutical synthesis, such as the preparation of Vismodegib, the trade name is Erivedge, the chemical name is 2-chloro-N-(4-chloro-3 -(Pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, developed by Curis, Genentech and Evotec in cooperation, was approved by the U.S. Food and Drug Administration (FDA) on January 30, 2012 ) marketing approval as a small molecule targeted inhibitor of the Hedgehog pathway for the treatment of basal cell carcinoma. | [Uses]
3-Bromo-4-chloroaniline is an amine derivative and can be used as an organic reagent. | [Synthesis]
Dissolve p-chloronitrobenzene in sulfuric acid aqueous solution, slowly add bromine reagent (bromine or potassium bromate), and react to obtain 3-bromo-4-chloroaniline. |
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