| Hazard Information | Back Directory | [Biological Activity]
PF-00356231 hydrochloride is a non-peptide, non-zinc-chelating matrix metalloprotease MMP-12 ligand and inhibitor (IC50=1.4 μM). It is specific for MMP-12 and forms the PF-00356231/MMP-12 complex. | [in vitro]
PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). It decreases the IC 50 values of MMP-12 ( 0.014 μM) and MMP-13 (0.27 μM) in the presence AH. | [target]
| MMP-12 < span> 1.4 μM (IC 50 ) | MMP13 0.65 nM (IC 50 ) | MMP-3 < span> 0.39 μM (IC 50 ) | MMP-8 1.7 μM (IC 50 ) | MMP-9 0.98 μM (IC 50 ) | | [storage]
Store at -20°C |
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