| Identification | Back Directory | [Name]
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid | [CAS]
80544-17-8 | [Synonyms]
NICA
MICAAcid
Cefixime Impurity 9
Cefixime side chain acid
(Z)-(2-Aminothiazol-4-yl)-
(2-AMINOTHIAZOL-4-YL)-METHOXYCARBONYLMETHOXYIMINOACETIC ACID
(Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-...
(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYCARBONYLMETHOXYIMINOACETIC ACID
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
(Z)-2-(2-METHOXY-2-OXOETHOXYIMINO)-2-(2-METHYLTHIAZOL-4-YL)ACETIC ACID
(2Z)-2-(2-amino-4-thiazolyl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid
4-Thiazoleacetic acid, 2-amino-α-[(2-methoxy-2-oxoethoxy)imino]-, (αZ)-
(Z)-2-(2-AMinothiazol-4-yl)-2-((2-Methoxy-2-oxoethoxy)iMino)acetic acid
(Z)-2-Amino-ALPHA-[(2-methoxy-2-oxoethoxy)-imino]-4-thiazoleacetic acid
(Z)-2-(t-MethoxycarbonylMethoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid
(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid | [Molecular Formula]
C8H9N3O5S | [MDL Number]
MFCD07782100 | [MOL File]
80544-17-8.mol | [Molecular Weight]
259.24 |
| Chemical Properties | Back Directory | [Melting point ]
>160°C (dec.) | [Boiling point ]
481.1±51.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
2.40±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
(Z)-2-(2-amino-4-thiazolyl)-2-methoxycarbonylmethoxyiminoacetic acid (cefixime side chain acid) is an important side chain for the synthesis of the third and fourth generation cephalosporins It is of great economic and practical value to strengthen its research and development. | [Uses]
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid can be used as an intermediate in organic synthesis. | [Preparation]
The synthesis of cefixime side chain acid takes tert-butyl acetoacetate as raw material, through the steps of oximation, etherification, chlorination, cyclization and hydrolysis, to synthesize (Z)-2-(2-amino Thiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid. |
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