| Identification | Back Directory | [Name]
Pancreatin | [CAS]
8049-47-6 | [Synonyms]
viobin
viokase
ilozyme
zypanar
pankreon
panteric
intrazyme
pancrex-v
PANCREATIN
Pancrease
Pankreatin
beefviokase
pankrotanon
pancreatine
diastasevera
PANCREATIN, 3X
Pancreatin-5.0
PANCREATIN 4X NF
Pancreatin Lipase
pancreatin pellets
Pancreatin, powder
PANCREATICKININASE
pancreatin medicinale
PANCREATIN 3X, U.S.P.
PANCREATIN 5X, U.S.P.
PANCREATIN 4X, U.S.P.
PANCREATIN 8X, U.S.P.
PANCREATIN,POWDER,USP
PANCREATIN 3X extrapure
PANCREATIN USP 23 POWDER
Pancreatin 4 x USP grade
Pancreatin Lipase (2 g)
PancreatineExPigPancreas
PANCREATIN 8X USP POWDER
PANCREATIN 4X USP GRANULAR
PANCREATIN 8X USP GRANULAR
PANCREATIN FROM HOG PANCREAS
Pancreatin(FromPigPancrease)
Pancreatin AMylase and Protease
pancreatin from porcine pancreas
Pancreatin,for biochemistry,powder
Pancreatin NB from porcine pancreas
PANCREATIN U.S.P. FROM HOG PANCREAS
Pancreatin, powder, for biochemistry
Pancreatin Amylase and Protease (2 g)
Pancreatin-11.0 (11XUSP) from hog pancreas
PANCREATIN 8X U.S.P. FROM PORCINE PANCREAS
PANCREATIN 4X U.S.P. FROM PORCINE PANCREAS
Pancreatin NB GMP Grade from porcine pancreas
Pancreatin Lipase (2 g) (COLD SHIPMENT REQUIRED)
Pancreatin from Porcine Pancreas (Activity,4xJP)
PANCREATIN, ACTIVITY EQUIVALENT TO 4X*U. S.P. SPEC.
PANCREATIN, ACTIVITY AT LEAST*EQUIVALENT TO U.S.P.
PANCREATIN, ACTIVITY EQUIVALENT TO 8X*U. S.P. SPEC.
PANCREATIN, ACTIVITY AT LEAST*EQUIVALENT TO 3X U.S.
Pancreatin from porcine pancreas Vetec(TM) reagent grade
Pancreatin from porcine pancreas,Pancreatin from hog pancreas
Pancreatin Amylase and Protease (2 g) (COLD SHIPMENT REQUIRED)
PANCREATIN 3X U.S.P. FROM HOG PANCREAS ACTIVITIES: 5 TIMES OF PANCREATIN U.S.P.(1X)
PANCREATIN 3X U.S.P. FROM HOG PANCREAS ACTIVITIES: 3 TIMES OF PANCREATIN U.S.P.(1X)
PANCREATIN FROM PIG PANCREAS CONTAINS AMYLOLYTIC, LIPOLYTIC AND PROTEOLYTIC ACTIVITIES
PANCREATIN ,1400 FIP-U G PROTEASE 24000 FIP-U G LIPASE 30000 FIP-U G AMYLASE PH EUR,4 X USP
PANCREATIN FROM PIG PANCREAS CONTAINS AMYLOLYTIC, LIPOLYTIC AND PROTEOLYTIC ACTIVITIES MEETS THE REQUIREMENTS OF THE BRITISH PHARMACOPOEIA 1968 | [EINECS(EC#)]
232-468-9 | [Molecular Formula]
N/A | [MDL Number]
MFCD00131789 |
| Chemical Properties | Back Directory | [Appearance]
Pancreatin is a yellowish to cream-colored,
amorphous powder with a strong odor. Slightly soluble
in water. Hazard Identification (based on NFPA-704 M
Rating System): Health 1, Flammability 1, Reactivity 0.
Sparingly soluble in water. | [density ]
1.4-1.52 | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
−20°C
| [solubility ]
Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether . | [form ]
powder
| [color ]
beige | [Stability:]
Stable. Incompatible with alcohols, strong acids. | [Water Solubility ]
Soluble in water. Insoluble in alcohol and ether. | [Merck ]
13,7075 | [LogP]
-1.3 at 20℃ and pH5.7-5.8 | [EPA Substance Registry System]
Pancreatin(8049-47-6) |
| Hazard Information | Back Directory | [Chemical Properties]
cream powder | [Potential Exposure]
It is an enzyme found in the pancreas
and is used in medicines and in treating leather and
textiles. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR
if heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get
medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation for Up to 8 hours after breathing
exposure is recommended, as symptoms may be delayed. | [Incompatibilities]
Dust may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, alcohols. | [History]
The first observations and experimental demonstrations that pancreatin could be used to improve protein and fat digestion in animals and human patients are from the 19th century, soon after Claude Bernard had revealed the essential role of pancreatic secretion in the digestion of foods. In 1859, the dutch physician Joseph Alexander Fles showed that the daily intake of calf pancreas extract could restore the digestion of fat in a diabetic patient who suffered from diarrhea and had large amounts of fat in the stools. In 1890, Abelmann showed that the consumption of fresh pig pancreas could improve protein and fat digestion in dogs after surgical removal of the pancreas. This is considered as the first experimental demonstration of enzyme replacement[1]. | [Uses]
Enzyme (digestant adjunct). | [Brand name]
Panteric (Parke-Davis). | [Biological Functions]
Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine. | [General Description]
Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase.
Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion. | [Biochem/physiol Actions]
Due to the enzymatic components such as trypsin, amylase and lipase, pancreatin hydrolyzes proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40?°C, will digest not less than 25 times its weight of casein in 60 minutes at pH7.5 at 40?°C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH9.0 at 37?°C. | [Clinical Use]
#N/A | [Safety Profile]
Moderately toxic by subcutaneous and intraperitoneal routes. | [Drug interactions]
Potentially hazardous interactions with other drugs
None known | [Metabolism]
Pharmacokinetic data are not available as the enzymes
act locally in the gastrointestinal tract. After exerting
their action, the enzymes are digested themselves in the
intestine. | [References]
[1] Amal Salhi . “Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices.” Biochimie 169 (2020): Pages 106-120. |
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