| Identification | Back Directory | [Name]
COTTONSEED OIL | [CAS]
8001-29-4 | [Synonyms]
cotton
LIPEX 109
cottonoil
cottondoil
nci-c50168
COTTONSEED OIL
COTTONSEEDOIL,NF
Oils, cottonseed
Baumwoellsamenoel
cottonseedoilacid
OIL OF COTTON SEED
Cottonseed Oil (1 g)
Cottonseed oil, pure
COTTONSEED OIL REFINED
Cottonseed Oil (1 g) (AS)
Gossypium hirsutum seed oil
COTTONSEED OIL, 1000MG, NEAT
Gossypium hirsutum, seed oils
Cottonseed oil，unhydrogenated
Cottonseedacidulatedsoapstock
cottonseed oil from cottonseed
deodorizedwinterizedcottonseedoil
Solventextractedcrudecottonseedoil
GOSSYPIUM HERBACEUM (COTTON) SEED OIL
Primebleachablesummeryellowcottonseedoil | [EINECS(EC#)]
232-280-7 | [Molecular Formula]
N/A | [MDL Number]
MFCD00130872 | [MOL File]
8001-29-4.mol | [Molecular Weight]
16.0425 |
| Chemical Properties | Back Directory | [Appearance]
pale yellow liquid | [density ]
0.91
| [refractive index ]
n20/D 1.471
| [Fp ]
113 °C | [storage temp. ]
2-8°C
| [solubility ]
Slightly soluble in ethanol (95%); miscible with carbon disulfide, chloroform, ether, hexane, and petroleum ether. | [form ]
Oil | [color ]
Yellow | [Odor]
at 100.00?%. bland | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. Heat and light sensitive. | [Dielectric constant]
1.3-1.4（0.0℃） | [EPA Substance Registry System]
Cottonseed oil (8001-29-4) |
| Hazard Information | Back Directory | [Chemical Properties]
pale yellow liquid | [General Description]
Odorless colorless to pale-yellow liquid. Less dense than water and insoluble in water. Hence floats on water. Freezing point 32°F. Contains principally the glycerides of palmitic, oleic and linoleic acids. | [Air & Water Reactions]
Insoluble in water. | [Reactivity Profile]
COTTONSEED OIL is sensitive to heat and light. | [Health Hazard]
None; is used as a food. | [Fire Hazard]
COTTONSEED OIL is combustible. | [Uses]
Cottonseed oil is a naturally occurring vegetable oil with insecticidal properties. It was used in the analysis of a calcimine compound. | [Uses]
Pharmaceutic aid (solvent). | [Definition]
Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. | [Production Methods]
Cottonseed oil is the refined fixed oil obtained from the seed of cultivated varieties of Gossypium hirsutum Linne or of other species of Gossypium (Fam. Malvaceae). The seeds contain about 15% oil. The testae of the seeds are first separated and the kernels are then exposed to powerful expression in a hydraulic press. The crude oil thus obtained has a bright red or blackish-red color and requires purification before it is suitable for food or pharmaceutical purposes.
Cottonseed oil is refined by treatment with diluted alkali to neutralize acids, decolorized with fuller’s earth or activated carbon, deodorized with steam under reduced pressure, and chilled to separate glycerides and resinous substances of higher melting point.
| [Pharmaceutical Applications]
Cottonseed oil is used in pharmaceutical formulations primarily as a solvent for intramuscular injections. It has been used in intravenous emulsions as a fat source in parenteral nutrition regimens, although its use for this purpose has been superseded by soybean oil emulsions. It has also been used as an adjuvant in cholecystography and as a pediculicide and acaricide. It has the nutritive and emollient properties of fixed vegetable oils. By virtue of its high content of unsaturated acid glycerides (especially linoleic acid), it is used for dietary control of blood cholesterol levels in the prophylaxis and treatment of atherosclerosis. It is used as a solvent and vehicle for injections; as an emollient vehicle for other medications; and orally as a mild cathartic (in a dose of 30mL or more). It can also retard gastric secretion and motility, and increase caloric intake. It has been used in the manufacture of soaps, oleomargarine, lard substitutes, glycerin, lubricants, and cosmetics.
Cottonseed oil has been used as a tablet binder for acetaminophen; for characterization of the hot-melt fluid bed coating process;(1) in the manufacturing of stable oral pharmaceutical powders; in encapsulation of enzymes; and as an aqueous dispersion in pharmaceutical coating. | [Safety]
Cottonseed oil emulsions have in the past been used in long-term intravenous nutrition regimens. A complex of adverse reactions,called the ‘overloading syndrome’has been seen with chronic administration of cottonseed oil emulsion. This consisted of anorexia,nausea,abdominal pain,headache,fever,and sorethroat. Signs of impaired liver function, anemia, hepatosplenomegaly, thrombocytopenia, and spontaneous hemorrhage due to delayed blood clotting have been reported. For parenteral nutrition purposes, cottonseed oil has been replaced by soybean oil,especially in pregnant women, where the use of cottonseed lipid emulsion has been associated with adverse effects.
A notable difference between the cottonseed oil emulsion and the soybean oil emulsion is the particle size.The cottonseed oil emulsion has much larger particles than the soybean oil emulsion. These larger particles may have been handled differently by the body, thus perhaps accounting for some of the toxic reactions.
| [storage]
Cottonseed oil is stable if stored in a well-filled, airtight, lightresistant container in a cool, dry place. Avoid exposure to excessive heat. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (IM injections, oral, capsule, tablet and sublingual preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
| Safety Data | Back Directory | [Safety Statements ]
24/25 | [WGK Germany ]
-
| [RTECS ]
GN2815000
| [F ]
8 | [HS Code ]
15122900 | [Safety Profile]
Questionable
carcinogen with experimental tumorigenic
data. Experimental teratogenic effects. An
allergen. Combustible liquid when exposed
to heat or flame. However, if allowed to
impregnate rags or oily waste, it can become
a dangerous hazard due to spontaneous
heating. To fight fire, use COa, dry chemical. | [Hazardous Substances Data]
8001-29-4(Hazardous Substances Data) |
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