| Identification | Back Directory | [Name]
Arachidonoyl LPA | [CAS]
799268-65-8 | [Synonyms]
20:4 Lyso PA
Arachidonoyl LPA
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt) | [Molecular Formula]
C23H42NO7P | [MDL Number]
MFCD22416838 | [MOL File]
799268-65-8.mol | [Molecular Weight]
475.56 |
| Hazard Information | Back Directory | [Description]
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; ). 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate. | [Uses]
Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states. |
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