| Identification | Back Directory | [Name]
FORSYTHOSIDE A | [CAS]
79916-77-1 | [Synonyms]
Forsythiaside
FORSYTHOSIDE A
Forsythiaside A
b-D-Glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-a-L-Mannopyranosyl)-,4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
2-(3,4-Dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-4-O-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]carbonyl-β-D-glucopyranoside | [Molecular Formula]
C29H36O15 | [MDL Number]
MFCD08460220 | [MOL File]
79916-77-1.mol | [Molecular Weight]
624.59 |
| Chemical Properties | Back Directory | [Melting point ]
>127°C (subl.) | [Boiling point ]
911.9±65.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.31±0.10(Predicted) | [color ]
Off-White to Light Beige | [CAS DataBase Reference]
79916-77-1 |
| Questions And Answer | Back Directory | [Overview]
Forsythiaside A is the phenylethanol glycoside component isolated from Forsythia. It has pharmacological effects such as antibacterial, antiviral, antioxidant, anti-infective and antipyretic. It is mainly used for content determination, identification, and pharmacological experiment and so on.
| [Chemical Properties]
This product appears as white crystalline powder. It is easily soluble in water, ethanol and methanol, but insoluble in ether and chloroform.
| [Pharmacological effects]
Forsythoside A has not only antibacterial, anti-infective and antipyretic effects, but also good anti-virus and antioxidant effects.
| [Preparation]
Extract 40 g of crushed forsythia leaves with 1200 mL 55% ethanol (volume fraction) at 74 ° C for 50 min, filter and extract twice. The filtrate was combined and concentrated under reduced pressure at 50 °C to recycle the ethanol, obtaining 665 mL of concentrated solution. 35 mL of absolute ethanol was added to give a forsythia leaf extract containing 5% ethanol (volume fraction). The forsythia leaf extract was adsorbed on a 2.6 cm x 25 cm AB-8 resin column and eluted with 50% ethanol to obtain a forsythia leaf extract. The extract of forsythia leaf was extracted for three times with water-saturated n-butanol. Recycle the n-butanol, and dry to obtain crude product. The crude product was separated in 8 cm x 50 cm C18 reverse phase silica gel column chromatography through elution with 30% methanol. Collect the eluent and obtain the pure compound of forsythoside A under reduced pressure.
| [Application]
It can be used for content determination, identification and pharmacological experiments.
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| Hazard Information | Back Directory | [Uses]
Forsythoside A is used as an antiinflammatory agent in traditional Chinese medicine. | [Definition]
ChEBI: Forsythiaside is a hydroxycinnamic acid. | [Biological Activity]
extracted from forsythia suspense (thunb.) vahl dried fruit;store the product in sealed, cool and dry condition | [in vivo]
Forsythiaside A (15-60 mg/kg; single dose; oral) improves OVA-induced asthma models in mice, dose-dependently activates Nrf2/HO-1 signaling, and attenuates OVA-induced lung histopathology[3].
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